Expression and clinical significance of galetin-3 and EGFR proteins in esophageal squamous carcinoma

VernacularTitle:galetin-3和EGFR蛋白在食管鳞状细胞癌中的表达及临床意义
Author: Huaping GU ; Peizhong SHANG
Publication Type:Journal Article
Keywords: Esophageal neoplasms; Carcinoma,squamous cell; Receptor,epidermal growth factor; Galectin-3
From: Journal of International Oncology 2011;38(8):630-632
CountryChina
Language:Chinese
Abstract: ObjectiveTo explore the correlation of expression of galetin-3 (Gal-3) and epidermal growth factor receptor (EGFR) with the biological behaviors in esophageal squamous carcinoma(ESC). MethodsImmunohistochemical method was used to examine the expression of Gal-3 and EGFR in 80 specimens of ESC. ResultsThe positive rates of Gal-3 and EGFR was 73.8％ (59/80)and 56. 3％ (45/80)respectively. The positive rates of Gal-3 and EGFR expression in the patients with poor differentiation, deep infiltration and lymph node metastasis was significantly higher than those with well differentiation, shallow infiltration and without lymph node metastasis ( P ＜ 0. 05 ). The high expression of Gal-3 and EGFR was correlated with higher percentage of death and lower survival rate ( P ＜ 0.05 ). ConclusionThe abnormal expression of Gal-3 and EGFR is closely related with the pathological biology behaviors of ESC. Gal-3 and EGFR can be regarded as objective indicators for forecasting metastasic potential of ESC and estimating prognosis of patients with ESC.