Profiling of human herpesvirus-8 (HHV-8) K15 allelotypes in squamous cell carcinoma tissue

VernacularTitle:鳞状细胞癌组织中HHV-8K15等位基因型研究
Author: Shuanghui LI ; Dezhi ZHANG ; Ying JIN ; Yan SHI ; Jianyong LIU ; Xiongming PU
Publication Type:Journal Article
Keywords: Carcinoma,squamous cell; Herpesvirus 8,human; Genes,K15; Alleles
From: Chinese Journal of Dermatology 2011;44(9):636-638
CountryChina
Language:Chinese
Abstract: Objective To study the relationship of HHV-8 K15 allelotypes in cutaneous and esophageal squamous cell carcinoma(SCC) tissue with tumorigenesis. MethodsSequence specific primernested PCR was performed to detect HHV-8 K15 gene and to determine its allelotype in paraffin-embedded tissue specimens from 40 patients with cutaneous SCC and 40 patients with esophageal SCC. Chi-square test was used for statistical analysis. ResultsHHV-8 K15 P allele was detected in 9(22.5％) of the cutaneous SCC specimens and 8(20％) of the esophageal SCC specimens. There was no significant difference in the detection rate of HHV-8 between cutaneous SCC and esophageal SCC specimens (P ＞ 0.05). HHV-8 K15 M allele was undetected in this study. ConclusionsSCC tissues appear to harbor only HHV-8 K15 P allele, and HHV-8 may play a part in the initiation and progression of SCC.