Immunosuppression regimen with Basiliximab induction in liver transplantation: efficacy and safety
10.3760/cma.j.issn.0254-1785.2011.09.009
- VernacularTitle:肝移植中应用巴利昔单抗诱导治疗的免疫抑制方案的疗效
- Author:
Weiqiang JU
;
Xiaoshun HE
;
Qiang TAI
;
Linwei WU
;
Anbin HU
;
Dongping WANG
;
Yi MA
;
Xiaofeng ZHU
;
Jiefu HUANG
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Immunosuppressive agents;
Basiliximab;
Treatment outcome
- From:
Chinese Journal of Organ Transplantation
2011;32(9):542-544
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effectiveness and tolerability of immunosuppressive regimen with daclizumab induction therapy. MethodsIn study group, 139 patients received immunosuppressive regimen with daclizumab induction therapy. In historical control group, 106 recipients received immunosuppressive regimen without daclizumab induction therapy. All patients were followed up at least for 1year. The acute rejection episodes, infectious and metabolic complications at one month and one year post-transplantation were compared between two groups.ResultsThe one-month incidence of acute rejection, new-onset diabetes mellitus, hypertension and infection was 7. 9 ％, 33. 8 ％, 21.6 ％ and 22. 3 ％, respectively in study group, as compared with 15. 1 ％, 72. 6 0％, 40. 6 ％ and 43. 4 ％, respectively in control group ( P ＜ 0. 05 ). The one-year incidence of acute rejection, new-onset diabetes mellitus, hypertension and hyperlipidemia was 10. 8 ％,5. 0 ％ ,4. 3 ％ and 7. 9 ％, respectively in study group, as compared with 19. 8 ％, 9. 4 ％, 8. 5 ％ and 14. 2 ％, respectively in control group (P＜0. 05). The one-year survival rate was comparable between two groups (P＞0. 05). ConclusionThe immunosuppressive regimen with daclizumab can enable early steroid withdrawal, significantly reduce acute rejection rate and various side effects mediated by longterm steroids use.
