The role of idehenone in the treatment of nervous system diseases New knowledge and new findings
10.3760/cma.j.issn.1673-4165.2011.08.001
- VernacularTitle:艾地苯醌在神经系统疾病治疗中的作用——新认识和新发现
- Author:
Zhong JI
;
Shengnan WANG
;
Suyue PAN
- Publication Type:Journal Article
- Keywords:
Ubiquinone;
Idebenone;
Antioxidants;
Oxidative stress;
Neuroprotective agents;
Brain ischemia;
Friedreich ataxia;
Alzheimer disease;
Mitochondria
- From:
International Journal of Cerebrovascular Diseases
2011;19(8):561-567
- CountryChina
- Language:Chinese
-
Abstract:
Idebenone is a synthetic analogue of coenzyme Q10. As a potent antioxidant,idebenone operates under low oxygen tension situations, protects cell membranes and mitochondria from oxidative damage through inhibiting lipid peroxidation, thereby protects against cerebral ischemia and nervous system damage. Idebenone also interacts with the mitochondrial electron transport chain and maintains the formation of ATP under ischemic conditions. Because idebenone has a good tolerability and safety, it is expected as a neuroprotective agent for the treatment of acute ischernic stroke. Studies in recent years have showed that idebenone has a certain therapeutic effect in a variety of nervous system diseases involving mitochondrial dysfunction and oxidative stress damage, such as mitochodrial encephalomyopathy, lactic acidosis, stroke-like episodes syndrome, Friedreich's ataxia, Alzheimer's diseases, Leber's hereditary optic neuropathy, and Duchenne muscular dystrophy. At present, some clinical trials in the mitochondria-related diseases and neuromuscular diseases are underway, and their results are expected to further expand the indications of idebenone.
