Genetic progression of familial gastric cancer
10.3760/cma.j.issn.1673-422X.2011.08.017
- VernacularTitle:家族性胃癌遗传学研究进展
- Author:
Lu GAN
;
Jiejun WANG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
E-cadherins;
Germline mutation
- From:
Journal of International Oncology
2011;38(8):611-614
- CountryChina
- Language:Chinese
-
Abstract:
The hereditary diffuse gastric cancer (HDGC) is associated with CDHI (E-cadherin gene)germline mutations, and accounts for about one-third of the familial gastric cancer (FGC) cases. The other two thirds FGC cases which are not fit the diagnosis standard of HDGC remain lack of clear molecular diagnosis basis. The current disposal of prophylactic gastrectomy in FGC according to E-cadherins genetic counseling, has clinical significance only in part of HDGC.
