Effects of liraglutide on fibroblast growth factor-21 and its receptors in insulin-resistant mice with hypoadiponectinemia
10.3760/cma.j.issn.1000-6699.2011.09.018
- VernacularTitle:利拉鲁肽对低脂联素血症诱导的胰岛素抵抗小鼠成纤维细胞生长因子21及其受体的影响
- Author:
Zongyu MIAO
;
Gangyi YANG
;
Ling LI
;
Bin SUN
;
Rui LIU
;
Chunmin LU
;
Zhihong ZHANG
;
Shengyong XU
;
Lin DU
- Publication Type:Journal Article
- Keywords:
Liraglutide;
Hypoadiponectinemia;
Fibroblast growth factor-21
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(9):775-777
- CountryChina
- Language:Chinese
-
Abstract:
The effects of liraglutide on glucose and lipid metabolism, fibroblast growth factor-21 ( FGF-21 )and its receptors (FGFR) in APoE-/-mice with hypoadiponectinemia were investigated.Hypoadiponectinemia facilitated disturbance in glucose and lipid metabolism and insulin resistance. Compared with the control mice, FGF21 mRNA and protein expressions of liver and adipose tissues as well as plasma FGF-21 level were significantly increased in ApoE-/-mice with hypoadiponectinemia, along with lowered expressions of FGFR1 and β-klotho mRNA in adipose tissues, and expressions of FGFR1-3 and β-klotho mRNA in liver. Liraglutide administration improved glucose and lipid metabolism and insulin resistance, and partially reversed the changes of FGF-21 and its receptors induced by hypoadiponectinemia.
