The role of T helper type 17 cells in the pathogenesis of HIV/tuberculosis-coinfected patients
10.3760/cma.j.issn.1000-6680.2011.10.009
- VernacularTitle:辅助性T细胞17在人类免疫缺陷病毒合并结核感染致病中的作用
- Author:
Qiaoli PENG
;
Mingxia ZHANG
;
Guiying LI
;
Jieyun ZHANG
;
Xiuyun ZHU
;
Yingxia LIU
;
Shuiteng LIU
;
Hongzhou LU
;
Boping ZHOU
;
Hui WANG
- Publication Type:Journal Article
- Keywords:
Human immunodeficiency virus;
T-lymphocytes,helper-inducer;
Tuberculosis
- From:
Chinese Journal of Infectious Diseases
2011;29(10):600-604
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the IL-17 expression in HIV/tuberculosis-coinfected patients and its role in the pathogenesis of this coinfection.MethodsFifty-four HIV infected patients were divided into three groups:simple HIV infected group,HIV with latent tuberculosis infection (HIV+ LTBI) group and HIV coinfected with active tuberculosis (HIV+ ATB) group.The whole blood intracellular cytokine staining was performed and samples were then detected by BD FACSCanto.The expressions of CD4+ IL-17+ T cells and CD4+ IFNγ+ T cells were analyzed using FACSDiva software.Comparison between groups was done by independent sample t test.ResultsThe CD4+ T cell count and viral load among these three groups were comparable.There were no significant difference of the expression of CD4+ IL-17+ T cells between simple HIV infected group and HIV+ LTBI group (1.40 ± 1.01) ％ vs (1.29±0.86) ％,(t=0.336,P＞0.05),but both of these two groups were much higher than HIV+ATB group (t=3.680,t=2.516,P＜0.05).There were no significant differences of the expression of CD4+ IFNγ+ T cells among these three groups [(32.8±24.0)％ vs (40.3±1 21.9) ％ vs (46.1±31.2)％,(t=-0.939,t=-1.602,t=-0.646,P＞0.05)].ConclusionThe Th17 response is down-regulated in HIV/tuberculosis-coinfected patients,which may play an important antitubercular role in the pathogenesis of coinfection.
