Blood-saving effect of acute plateletpheresis and back-transfusion in patients undergoing open heart surgery with CPB
10.3760/cma.j.issn.0254-1416.2011.07.010
- VernacularTitle:急性血小板分离回输对体外循环心脏直视手术患者的血液保护效果
- Author:
Haiyan WEI
;
Hongwei SHI
;
Hongguang BAO
;
Yali GE
;
Yuan ZHANG
;
Xin CHEN
- Publication Type:Journal Article
- Keywords:
Blood platelets;
Blood transfusion,autologous;
Postoperative hemorrhage;
Cardiopulmonary bypass;
Cardiac surgical procedures
- From:
Chinese Journal of Anesthesiology
2011;31(7):812-815
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo assess the blood-saving effect of acute plateletpheresis (APP) and back-transfusion in patients undergoing open.heart surgery with CPB.MethodsThirty ASA Ⅱ or Ⅲ patients aged 41-63 yr weighing 52-72 kg undergoing open heart surgery with CPB were randomly divided into 2 groups (n =15 each):control group (group C) and APP group.In APP group,platelet-rich plasma was harvested immediately after induction of anesthesia and transfused back to the patient after termination of CPB and neutralization of heparin with protamine.In group C plateletpheresis was not performed.Hb,Plt,PT,APTT and Fib were measured before induction and at 1,24 and 48 h after operation.CPB time,aortic crossclamping time,postoperative chest tube drainage and blood product transfusion requirements were recorded.ResultsIn APP group the volume of the whole blood processed for plateletpheresis was (1285 ± 185) ml and ( 192 ± 38) ml of platelet-rich plasma was sequestered.The platelet count of the sequestered plasma was(817 ± 282) × 109/L,accounting for (21 ± 3) ％ of the total number of Pit in the whole blood volume.The plateletpheresis took (35 ± 10) min.The platelet count at 1 h after operation was significantly higher in APP group than in group C.The volume of postoperative chest tube drainage at 24 h after operation was significantly lower in APP group than in group C.Less allogeneic RBC and Plt were transfused in APP group than in group C.There was no significant difference in other variables between the 2 groups.ConclusionAPP has blood-saving effect in patients undergoing open heart surgery with CPB.
