Expression of matrix metalloproteinase-2,cysteine rich protein61 and CD25 In esophageal carcinoma and their significance
10.3760/cma.j.issn.1673-4904.2011.24.011
- VernacularTitle:基质金属蛋白酶-2、半胱氨酸富集蛋白61及CD25在食管鳞癌中表达及其意义
- Author:
Xiaofeng CHEN
;
Lijia JIANG
;
Xiufang CHEN
;
Xuliang MA
;
Qiong YE
;
Lixiang ZHANG
;
Liangda JIN
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Matrix metalloproteinase 2;
C ysteine rich protein 61
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(24):27-29
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo determine the expression of matrix metalloproteinase-2 (MMP-2),cysteine rich protein 61 (Cyr61) and CD25 in esophageal carcinoma and investigate their clinical significance.MethodThe expression of MMP-2, Cyr61 and CD25 in 68 cases of esophageal tumor tissues (esophageal carcinoma group ) and part-cancer( para-cancer group ) and 68 cases of reflux esophagitis (control group ) was detected by immunohistochemical method and the results were statistically analysed. ResultsThe positive expression rates of MMP-2,Cyr61 and CD25 were 82.35％(56/68), 73.53％(50/68) and 89.71％(61/68)respectively in esophageal carcinoma group,there were significant differences compared with those in paracancer group and control group(P ＜ 0.05) ; while there was no significantdifference between para-cancer group and control group (P ＞ 0.05 ). The positive expression rates of MMP-2, Cyr61 and CD25 in esophageal carcinoma group in different T stage, N stage and M stage all had statisticall differences (P ＜ 0.05),while there was no significant difference in different degree of differentiation (P ＞ 0.05 ). ConclusionMMP-2,Cyr61 and CD25 is highly expressed in esophageal carcinoma,there is some significance for understanding the occurrence, development and prognosis of esophageal carcinoma.
