Founder mutations of BRCA1 and BRCA2
10.3760/cma.j.issn.1673-422X.2011.08.002
- VernacularTitle:BRCA1和BRCA2的始祖突变
- Author:
Yuxia WANG
;
Juan ZHANG
;
Yuntao XIE
- Publication Type:Journal Article
- Keywords:
Genes,BRCA1;
Genes,BRCA2;
Mutation
- From:
Journal of International Oncology
2011;38(8):566-568
- CountryChina
- Language:Chinese
-
Abstract:
Mutations of BRCA1 and BRCA2 are closely related to developing of breast cancer andovarian cancer. There are a great diversity of founder mutations of BRCA1 and BRCA2. Their types and fre quency are greatly different in populations from different geographic regions and ethnicities. In particular ethnicgroups, founder mutations show a high frequency due to a founder effect. Compared with the expensive wholegenomic scan, screening of founder mutations which could provide information for the prevention and treatmentof related cancer is more convenient and easy to popularize with low cost.
