Association of obesity and hyperandrogenemia with insulin resistance in women with polycystic ovary syndrome
10.3760/cma.j.issn.1000-6699.2011.09.007
- VernacularTitle:多囊卵巢综合征患者肥胖和高雄激素血症与胰岛素抵抗的相关性
- Author:
Jin LI
;
Cheng XU
;
Huijie ZHANG
;
Ji HONG
;
Guang NING
;
Xiaoying LI
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Insulin resistance;
Obesity;
Hyperandrogenemia
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(9):733-735
- CountryChina
- Language:Chinese
-
Abstract:
Thirty healthy women and 101 patients with polycystic ovary syndrome (PCOS) were recruited. According to serum testosterone (T) level and homeostasis model assessment for insulin resistance (HOMA-IR) ,the correlation of T and body mass index (BMI) with insulin resistance was analyzed. The results showed that there were 39. 8% normal,24. 5% overweight,and 35.7% obese among 101 PCOS patients. However,there were no significantly differences in BMI, fasting plasma glucose ( FPG ), triglyceride ( TG ), total cholesterol ( TC), low-density lipoprotein-cholesterol ( LDL-C), high-density lipoprotein-cholesterol ( HDL-C ), and HOMA-IR levels between PCOS patients with hyperandrogenemia ( T ≥ 0. 51 μg/L) and normal androgenemia ( T < 0. 51 μg/L). BMI, FPG, TG, TC, and LDL-C levels were higher and HDL-C level was lower in patients with insulin resistance( HOMA-IR ≥ 2. 29 ) than in patients without insulin resistance ( HOMA-IR < 2. 29, P<0. 05 or P< 0. 01 ). Serum T levels were not significantly different between two groups. HOMA-IR was significantly correlated with BMI(P<0. 01 ), not with serum T, suggesting that the gain of body weight is correlated with insulin resistance independent of serum T level.