Vectors employed for malignant glioma gene therapy
10.3760/cma.j.issn.1673-422X.2011.08.011
- VernacularTitle:脑胶质瘤基因治疗载体
- Author:
Jieying ZHANG
;
Xiaowen WANG
;
Jintian TANG
- Publication Type:Journal Article
- Keywords:
Gliomas;
Gene therapy;
Genetic vectors
- From:
Journal of International Oncology
2011;38(8):592-595
- CountryChina
- Language:Chinese
-
Abstract:
The vectors play an important role in gene therapy by transporting the therapy genes into target tumor cells. At present there are mainly two kinds of gene vectors, including biological and non-biological vectors. Biological vectors, including virus, bacteria and stem cells, have good target activity and can efficiently delivery the genes into target tumor cells, but have potential genetic hazards.However, non-biological vectors, including liposomes and nanoparticles, can be simplely prepared with high genetic safety, but they can not transport the genes efficiently. Therefore, establishing safe and effective malignant glioma gene treatment system and finding gene vectors with good target activity become the research focus.
