Study the FOLR1 mRNA expression of 40 esophageal cancerous tissues and relationship between ABO blood group
10.3760/cma.j.issn.1008-1372.2011.08.010
- VernacularTitle:40例食管癌组织中FOLR1mRNA表达情况及ABO血型关系研究
- Author:
Jing YU
;
Xuanzhi LIU
;
Huaiqi YAO
;
Suzuan CHEN
;
Guanghua GUO
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms/ME;
Folic acid/ME;
ABO blood-group system
- From:
Journal of Chinese Physician
2011;13(8):1045-1048
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the expressions of folate receptor alpha (FOLR1) in 40 esophageal cancerous tissues and its relevance of ABO blood group.MethodsABO blood groups were analyzed in 40 patients.Immunohistochemistry (IHC) and real-time quantitative reverse transcription PCR detection were used to detect the expression of folate receptor in cancer and adjacent tissues.Results20％of esophageal cancer was suspected positive (+), 50％ of cancer adjacent tissue was suspected positive (+), 10％ were positive (+), the difference was statistically significant (x2 = 14.48, P ＜0.01).Real Time RT-PCR analysis showed FOLRI low expression in esophageal cancer and adjacent tissues, compared to normal esophageal mucosa, the differences were statistically significant (F1 =53.247, F2 = 116.500, P ＜0.01).ABO blood type and FOLRi in esophageal cancer patients were not significant correlated (P =0.647, P ＞0.05).ConclusionsFOLRI expression was decreased in the esophageal lesions compared with adjacent tissues.Detection of FOLRl expression level in esophageal cancerous tissues and the paired adjacent tissues was helpful for judging the extent of disease and guiding surgery treatment.The FOLRI expression level in esophageal carcinoma tissues had no relationship with ABO blood types.
