Layer-by-layer assembled selenium containing mimic artificial blood vessels with catalyzing NO generation
10.3760/cma.j.issn.1673-4181.2011.04.001
- VernacularTitle:仿生构建具有一氧化氮自催化生成功能的人工血管材料
- Author:
Yandong LI
;
Kai WANG
;
Meimei KONG
;
Wenjie WU
;
Jun AN
;
Siyuan CHEN
;
Yanhang HONG
;
Deling KONG
;
Shufang WANG
- Publication Type:Journal Article
- Keywords:
Self-assembly;
Bionic;
Nitric oxide;
Catalytic generation;
Artificial vessels
- From:
International Journal of Biomedical Engineering
2011;34(4):193-196
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveA new style of artificial vessel scaffold was designed making the use of property of organoselenium catalyzing the releasing of Nitric oxide (NO). MethodsSelenium-containing catalyst organoselenium immobilized polyethyleneimine (SePEI) as polycation and polyglutamic acid (PGA) as polyanion were alternately coated onto the surface of polycaprolactone (PCL) nanofiber scaffolds obtained by electrospinning to form the blood vessel scaffold. Self-assembly was characterized by UV and atomic absorption qualitatively and quantitatively. Catalytic generation of NO from the NO donors- RSNOs was tested under the existence of reducing agent RSH. Biological properties were also evaluated. Results The NO release was relatively stable with no significant burst appeared, and still could be detected after 80 hours of catalyzing. The material was proved to show little cytotoxicity, and displayed significant effect in inhibiting of platelet aggregation through biological testing. Conclusion The new style of artificial vessel scaffold has good effect on improving the biological properties of materials.
