Study on the expression of Glut1, HIF-1α and Ki-67 in hepatocellular carcinoma and their relationship
10.3760/cma.j.issn.1008-1372.2011.08.004
- VernacularTitle:葡萄糖转运蛋白1、缺氧诱导因子-1α和Ki-67在肝细胞癌中的表达及其相关性研究
- Author:
Xinmu ZHOU
;
Yiling ZHU
;
Shaojie XU
;
Hongming SUN
;
Chaoyong TU
;
Qingrong LI
- Publication Type:Journal Article
- Keywords:
Glucose transport proteins,facilitative/ME,Hypoxia-inducible factor 1/ME;
Ki-67antigen/ME;
Carcinoma,hepatocellular/ME
- From:
Journal of Chinese Physician
2011;13(8):1022-1025
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the expression of Glut1, HIF-1α and Ki-67 in hepatocellular carcinoma (HCC) and their relationship between their expression and clinicopathological features.MethodsImmunohistochemical study (EnVision method) for Glut1, HIF-1a and Ki-67 were performed on tissue microarray which consisted of 171 cases of HCC, 55 cases of adjacent non-neoplastic liver tissues, and 22cases of normal liver tissues.ResultsThe expression rate of Glut1 ,HIF-1α and ki-67 in 171 cases of HCC was 15.2％, 19.9％ and 66.1％, respectively, which was much higher than that in the adjacent non-neoplastic liver tissues (1.8％ ,1.8％and 5.5％) and normal liver tissues(all negative).The expressions of Glut1 and HIF-1α were positively correlated with the differentiation degree of HCC and TNM stage(P ＜0.01, P ＜0.05).The expression of ki-67 was positively correlated with the differentiation degree of HCC.There was a significant positive correlation between the expressions of Glut1 and HIF-1α in HCC (r1 =0.553, P ＜0.05), the expressions of Glut1 and HIF-1α were positively correlated with ki-67(r2 =0.560,r3 =0.613, P ＜0.05).ConclusionsGlut1, HIF-1α and ki-67 may play a role in the tumorigenesis and progression of HCC in some degree.Combined detection of Glut1, HIF-1α and Ki-67 may be helpful to judge the degree of malignancy and potential metastasis and evaluate the prognosis.
