The association between ACE gene insertion/deletion polymorphism and type 2 diabetes in Han Chinese from Chenzhou area
10.3760/cma.j.issn.1008-1372.2011.08.009
- VernacularTitle:郴州地区汉族人群ACE基因I/D多态性与2型糖尿病的关系
- Author:
Qishan ZHANG
;
Qiming YANG
;
Lin LI
;
Yanghua JIANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2/GE;
Peptidyl-dipeptidase A/GE;
Polymorphism,genetic
- From:
Journal of Chinese Physician
2011;13(8):1041-1044
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo determine the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism in Han ethnic patients with type 2 diabetes in Chenzhou area of Hunan province,and to assess the assoeiation between this polymorphism and diabetes.MethodsThis study was cross-sectional designed.Samples were taken by random sampling method from diabetes, prediabetes and euglycemia subjeers.ACE gene polymorphism I/D were examined by PCR.Genotype was classified as I1, ID, or DD based on positive or negative insertion/deletion allele.ResultsThis study showed significant differences of ages (X2 =32.09, P ＜0.01), body mass index (BMI) (X2 =16.10, P ＜0.01), family history (X2 =20.42, P ＜0.01) and serum triglyceride (F =21.289, P ＜0.01) among three groups, and diabetes group tended to have higher value.Frequency of genotype II, ID, DD were 72(56.3％) ,52(40.6％) and 4(3.1％) in diabetes, 64(64.0％) ,30(30.0％) and 6(6.0％) in pre-diabetes subjects, 81 (72.3％),29(25.9％)和 2(1.8％) in euglycemia subjects, consecutively.Chi-square analysis showed statistically significant association between ID + DD vs.Ⅱ genotype and diabetes (x2 = 6.68, P ＜ 0.05).Logistic regression analysis showed four variables that significantly influence to diabetes, namely ACE gene polymorphism, family history of diabetes, BMI, and serum triglyceride level.ConclusionsACE ID + DD genotype had significant relationship with diabetes in Chenzhou Han ethnic population, Hunan province, China.
