Value of dobutamine stress echocardiography combined with myocardial contrast echocardiography in early diagnosis of coronary artery disease
10.3760/cma.j.issn.1004-4477.2011.08.003
- VernacularTitle:多巴酚丁胺负荷超声心动图结合心肌灌注造影早期诊断冠心病的价值
- Publication Type:Journal Article
- Keywords:
Echocardiography;
Dobutamine;
Microbubbles;
Coronary disease;
Myocardial ischemia
- From:Chinese Journal of Ultrasonography
2011;20(8):652-655
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of high-dose dobutamine stress echocardiography (DSE) combined with myocardial contrast echocardiography (MCE) in early diagnosis of coronary artery disease(CAD). Methods Dobutamine stress MCE and SonoVue contrast infusion were performed before an elective percutaneous coronary intervention in 38 patients with suspected CAD. The total and regional perfusion and wall motion (WM) were scored as normal or abnormal and attributed to the three main epicardial coronary arteries using a 16-segment left ventricular model. Results An intermediate stress level was obtained in 22 (58 ％) patients, and 9(24 ％ ) patients obtained peak stress. Twenty seven of 38 patients were diagnosed as CAD by quantitative coronary angiography. A perfusion defect was detected in 89％ and WM abnormality in 52％ of the patients at peak stress ( P ＜0.01). By perfusion,71％ of stenoses were both detected and correctly anatomically located,compared to 41 ％ by WM ( P ＜0.01). Conclusions DSE combined with MCE can increase the sensitivity of myocardial ischemia detection. Perfusion scoring is superior to WM scoring during stress MCE for diagnosing significant CAD. As a new non-invasive method,DSE combined with MCE could be used in early diagnosis of CAD.
