Progress of CD4 + CD25 + regulatory T cells in pathogenesis of idiopathic thrombocytopenic purpura
10.3760/cma.j.issn.1673-4408.2011.05.005
- VernacularTitle:CD4+CD25+调节性T细胞在特发性血小板减少性紫癜发病机制中的作用
- Author:
Xiaoqun LIU
- Publication Type:Journal Article
- Keywords:
CD4+ CD25 regulatory T cell;
Foxp3;
Idiopathic thrombocytopenic purpura
- From:
International Journal of Pediatrics
2011;38(5):437-440
- CountryChina
- Language:Chinese
-
Abstract:
CD4 + CD25 + regulatory T cells(Treg) are thought to be a subgroup of mature CD4 + T cells.Forkhead winged helix transcription factor-3 (Foxp3)is specifically expressed on them and plays a key role in their development and function. CD4 + CD25 + Treg cells can maintain the stabilization of internal environment by two principal pathways to suppress the immunological function: the direct suppression of the target cells by cell-contact and the secretion of suppressor cytokines.At present,it has been considered that decreased number and dysfunction of CD4+ CD25+ Treg cells are closely related to pathogenesis of autoimmune disease. Recent findings show that CD4+ CD25+ Treg cells play an important role in pathogenesis of idiopathic thrombocytopenic purpura.
