Development of the relationship of nesprins with some human disease
10.3760/cma.j.issn.1673-4408.2011.05.013
- VernacularTitle:nesprins与某些人类疾病研究进展
- Author:
Gao FANG
- Publication Type:Journal Article
- Keywords:
nesprins;
Nuclear envelop proteins;
Disease
- From:
International Journal of Pediatrics
2011;38(5):465-467
- CountryChina
- Language:Chinese
-
Abstract:
nesprins are a lately discovered family of ubiquitously expressed nuclear envelop proteins. By now, four genes have been identified, which are nesprin-1, nesprin-2, nesprin-3, nesprin-4. They are thought to regulate nuclear anchorage and organelle migration, and are also localized at the inner nuclear membrane, where they bind with laminA/C and emerin. They are expressing in a variety of tissues, especially in cardiac muscle,skeletal muscle, smooth muscle and nerve system. Additionally, they may contribute to a broad range of human disease syndromes,suchas Emery-Dreifuss muscular dystrophy,Meckel-Gruber syndrome.This reviewsmmmarizes the relationship of nesprins with some diseases.
