Progress on correlation between connexin 43 and cardiovascular disease
10.3760/cma.j.issn.1673-4408.2011.05.015
- VernacularTitle:Connexin43与心血管疾病关系的研究进展
- Author:
Wu YAO
- Publication Type:Journal Article
- Keywords:
Connexin;
Cardiovascular diseases;
Expression regulation
- From:
International Journal of Pediatrics
2011;38(5):470-473
- CountryChina
- Language:Chinese
-
Abstract:
As the most important gap junction protein, connexin 43 ( Cx43 ) is the most important connexin in the mammalian heart.Recent studies suggest that it plays an important role in heart development, cardiac electrophysiological activity and cell repair after myocardial ischemia.Cx43 abnormity is an important cause of many cardiovascular diseases including congenital heart disease, ischemic heart disease, arrhythmias and hypertension.The expression of Cx43 is regulated by various factors, including methylation, histone modification and non-coding RNA regulation, etc. These abnormal regulations may be important for the development of diseases.
