Aberrant methylation of Wnt signaling pathway in lymphoblastic leukemia
10.3760/cma.j.issn.1673-4408.2011.05.022
- VernacularTitle:Wnt信号通路异常甲基化与淋巴细胞白血病的关系
- Author:
Zhao CHAN
- Publication Type:Journal Article
- Keywords:
Wnt signaling pathway;
Methylation;
Lymphoblastic leukemia
- From:
International Journal of Pediatrics
2011;38(5):494-496
- CountryChina
- Language:Chinese
-
Abstract:
Wnt signaling plays an important role in blood tumorigenesis through the complex signal transduction pathways.Aberrant methylation of Wnt signaling inhibitor gene promoter leads to loss of function, which is involved in leukemia incidence and affects the relapse rate, disease free survival and overall survival.Demethylating agents or specific inhibitors of Wnt pathway, which was added in cell culture, increased apoptosis.Analysis of Wnt signaling pathway by aberrant methylation is important to guide lymphocytic leukemia prognosis and individual treatment.
