Polymorphism of gamma-glutamyl hydrolase and methotrexate sensitivity
10.3760/cma.j.issn.1673-4408.2011.05.023
- VernacularTitle:GGH基因多态性与甲氨蝶呤药物敏感性的关系
- Author:
Honghong ZHANG
- Publication Type:Journal Article
- Keywords:
Gamma-Glutamyl hydrolase;
Genetic polymorphisms;
Methotrexate;
Drug sensitivity
- From:
International Journal of Pediatrics
2011;38(5):497-500
- CountryChina
- Language:Chinese
-
Abstract:
Gamma-glutamyl hydrolase (GGH) plays an important role in methotrexate (MTX)polyglutarmation. High level of GGH has been associated with cellular resistance to MTX. Recent studies have demonstrate that some polymorphisms of GGH could change the expression and catalytic activity of the enzyme,causing interindividual difference in MTX cytotoxicity. No study about GGH was reported in Chinese population. This paper reviewed the advances about the structure and function of GGH and its gene, and the advances in associations between polymorphisms of GGH and MTX sensitivity.
