The expression and its significance of EMMPRIN and MMP-9 in epithelial ovarian carcinoma
10.3760/cma.j.issn.1008-1372.2011.08.013
- VernacularTitle:细胞外基质金属蛋白酶诱导因子及基质金属蛋白酶9在上皮性卵巢癌中的表达及意义
- Author:
Hongying WANG
;
Huanying XI
;
Junlong XU
- Publication Type:Journal Article
- Keywords:
Extracellnlas matrix proteins/ME;
Matrix metalloproteinase 9/ME;
Ovarian neoplasms/ME
- From:
Journal of Chinese Physician
2011;13(8):1055-1059
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the expression of EMMPRIN and MMP-9 in epithelial ovarian carcinoma and the relationship of invasion and metastasis in ovarian carcinoma.MethodsThe expression of EMMPRIN and MMP-9 was detected in 55 malignant and 21 benign ovarian neoplasms by immunohistochemical Sp method.ResultsThe expression rate of EMMPRIN and MMP-9 in malignant, benign epithelial ovarian tumors was 89.1％, 14.3％ and 96.4％, 23.8％, respectively.There were significance different between malignant tumors and benign tumors.In ovarian cancer, the expression of EMMPRIN in tumor cells had a significant relevance to clinical phases and pathology types, while the expression of EMMPRIN in stromal ceils was associated with clinical phases, pathology types and pathological grades.The expression of MMP-9 in tumor cells had a significant relevance to clinical phases and pathology types while the expression of MMP-9 in stromal cells was associated with clinical phases, pathology types and ascites.ConclusionsEMMPRIN and MMP-9 were detected not only in tumor cells, but also in stoma cells.High expression of EMMPRIN and MMP-9 may play an important role in the pathogenesis of ovarian cancer, and their synergistic effect may act as an important factor in promoting the invasion and metastasis of ovarian cancer.
