Effects of succus entericus reinfusion with continuous enteral nutrition on the barrier function of intestinal mucosa in patients with stomal type fistulas
10.3760/cma.j.issn.1674-635X.2011.04.006
- VernacularTitle:肠液回输对肠外瘘患者小肠黏膜屏障功能的影响
- Author:
Jinguo ZHU
;
Ren YU
;
Hengfa GE
;
Baofei JIANG
;
Guoquan TAO
- Publication Type:Journal Article
- Keywords:
Succus entericus reinfusion;
Stomal type fistula;
Intestinal intraepithellal lymphocytes;
Proliferating cell nuclear antigen
- From:
Chinese Journal of Clinical Nutrition
2011;19(4):239-241
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the effect of succus entericus reinfusion with continuous enteral nutrition on the barrier function of intestinal mucosa and nutritional status in patients with stomal type fistulas. Methods Sixteen patients with stomal type fistula from July 1995 to May 2008 were enrolled in the study. A]l patients met the following conditions: gut function returned normal; abdominal infection was controlled; total enteral nutrition was provided ; and the length of small intestine for succus entericus reinfusion was more than 50 cm. Intestinal mucosa was taken at 25 to 30 cm away from stoma of fistula by endoscope 0, 7, and 14 days after reinfusior. Hematoxylineosin staining was performed to count the number of intestinal intraepithelial lymphocytes (IIELS). In addition,proliferating cell nuclear antigen (PCNA) was measured with immunohistochemical staining. Serum protein levels were determined by immunonephelometry. ResultsThe percentage of IIELS in intestinal mucosa ( 19.06％ ±4.81％ vs. 12.81％ ±2.95％, P=0.000) and the percentage of PCNA positive cells ( 12.13％ ±4.33％ vs.6.44％ ± 2.34％, P =0.000) 14 days after succus entericus reinfusion were significantly higher than those on the day of reinfusion. Serum fibronectin level increased from ( 152.80 ± 16.50 ) to ( 227.05 ± 45.36 ) mg/L ( P =0.000), and transferring protein level increased from ( 2.16 ± 0.52 ) to ( 2.62 ± 0.41 ) g/L ( P =0.017 ) 14days after succus entericus reinfusion. ConclusionSuccus entericus reinfusion is effective in protecting the intestinal mucosa in patients with stomal type fistulas.
