Effects of different nutrition methods on the number and activity of natural killer cells in liver after hepatectomy in cirrhotic rats
10.3760/cma.j.issn.1674-635X.2011.04.010
- VernacularTitle:不同营养方式对肝硬化大鼠肝切除术后肝脏自然杀伤细胞的影响
- Author:
Shimin LUO
;
Jian LIU
;
Jie CAO
;
Weimin TAN
;
Jianwei LUO
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis;
Hepatectomy;
Parenteral nutrition;
Enteral nutrition;
Natural killer cell
- From:
Chinese Journal of Clinical Nutrition
2011;19(4):255-258
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the effects of different nutrition methods on the number and activity of natural killer (NK) cells in liver after hepatectomy in cirrhotic rats. MethodsTwenty thioacetamide-induced cirrhotic rats were randomly divided into enteral nutrition (EN) group ( n =10) and parenteral nutrition (PN) group ( n =10), in which EN or PN was administered for 5 consecutive days 1 day after hepatectomy. The percentage of the NK cells in livers was examined by flow cytometry. Activity of NK cells was measured by 4 h51Cr-release assay.ResultsCompared with the PN group, the percentage (22.2 % ± 1.7% vs. 17.4% ± 1.8%, P =0.000) and the activity of NK cells (41.6% ± 2.3% vs. 37.1% ± 2.2%, P =0.000) in the livers were significantly higher in the EN group. ConclusionEN after posthepatectomy can ameliorate the percentage and the activity of NK cells in the livers in cirrhotic rats.