Progress on vitamin A for newborn respiratory distress
10.3760/cma.j.issn.1673-4408.2011.05.012
- VernacularTitle:维生素A在治疗新生儿肺疾病中的研究进展
- Author:
Heqiang SUN
;
Hao ZHOU
- Publication Type:Journal Article
- Keywords:
Newborn;
Chronic lung disease;
Vitamin A;
lntratracheal administration
- From:
International Journal of Pediatrics
2011;38(5):461-464
- CountryChina
- Language:Chinese
-
Abstract:
Chronic lung disease (CLD) of prematurity is the major cause of long-term disability of extremely low birth weight ( ELBW ) premature infants, and it is the most cost consumptive disease in neonatal intensive care unit graduates.Vitamin A plays an important role in the development of premature lung. Nevertheless, premature infants are prone to vitamin A deficiency.Oral supplementation of vitamin A does not alter the incidence of CLD in ELBW infants.Intramuscular administration of vitamin A reduced the incidence of CLD.The treatment is considered painful and this way is not routinely practiced.Vitamin A is systemically bioavailable after intratracheal administration with surfactant in an animal model of newborn respiratory distress.
