The study of relationship between glucose-6-phosphate dehydrogenase deficiency and hyperbifiliru-binemia
10.3760/cma.j.issn.1673-4408.2011.05.019
- VernacularTitle:G-6-PD缺乏症和新生儿高胆红素血症
- Author:
Junbin OU
- Publication Type:Journal Article
- Keywords:
Glucose-6-phosphate dehydrogenase deficiency;
Hyperbilirubinemia;
Neonatal;
Bilirubin;
Hemolysis;
G ene
- From:
International Journal of Pediatrics
2011;38(5):484-486
- CountryChina
- Language:Chinese
-
Abstract:
Glucose-6-phosphate dehydrogenase deficiency is a common monogenic inheritance disorder, with extensive distribution around the world and very high gene frequency. Acute hemolysis may lead to rapidly rising of serum total bilirubin concentrations and may eventually result in bilirubin encephalopathy.The hyperbilirubinemia is the result of abnormal bilirubin metabolism due to complex interactions between G-6-phosphate dehydrogenase deficiency and the genetic co-expression. Neonatal unconjugated hyperbilirubinemia is one of the most common conditions encountered by the practicing pediatricians.
