Mechanisms of mesenchymal stem cells' effect on the graft-versus-host disease after hematopoietic stem cell transplantation
10.3760/cma.j.issn.1673-4408.2011.05.025
- VernacularTitle:间充质干细胞对造血干细胞移植中移植物抗宿主病的防治机制
- Author:
Xue NING
- Publication Type:Journal Article
- Keywords:
Mesenchymal stem cells;
Graft-versus-host disease;
Hematopoietic stem cell transplantation;
Immunomodulatory
- From:
International Journal of Pediatrics
2011;38(5):503-505
- CountryChina
- Language:Chinese
-
Abstract:
Allogeneic hematopoietie stem cell transplantation(alloHSCT) is a potentially curative therapy for patients with hematological malignant disease, autoimmune disease or hereditary disease.However, graftversus-host disease (GVHD), which is one of the most serious complications, influences the prognosis of alloHSCT. Mechanisms of GVHD is so complicated that there is still no perfect way to treat the patients at present. Recently, mesenchymal stem cells(MSC) become new hotspots because of their immunomodulatory properties and potential to suppress alloreactive T cell responses.Animal experiments showed that MSC were effective during the prevention and treatment of GVHD. This paper is to summarize the acting mechanism of MSC' effect on the prevention and treatment of GVHD after alloHSCT.
