Effects of bone morrow stromal cells transplantation on neurological behavior and Bax expression in rats with traumatic brain injury

VernacularTitle:骨髓基质干细胞移植对脑挫伤大鼠神经行为学和Bax表达的影响
Author: Yunhui ZHANG ; Qiqin DAN ; Shan ZHAO ; Shenglan WANG ; Bing YUAN ; Lan TAN
Publication Type:Journal Article
Keywords: Brain injuries; Myeloid progenitor cells; Neurobehavioral manifestations; Bax expression
From: Chinese Journal of Trauma 2011;27(8):752-755
CountryChina
Language:Chinese
Abstract: ObjectiveTo explore the effects of bone morrow stromal cells (BMSCs) on the neurological behavior of rats with traumatic brain injury (TBI).MethodsTwenty-four SD rats were randomly and equally divided into control group, TBI group and BMSC group. The weight-drop device was adapted to establish the TBI model. The injury severity and its outcome were evaluated by a set of criteria termed neurological severity score (NSS). Brain tissues were harvested at day 14 to observe the survival and migration of the transplanted cells.Bax expression was detected by RT-PCR. Results NSS was (12 ±3 ) points in the TBI group, significantly higher than (7 ± 1 ) points in the BMSC group (P ＜0.05). The transplanted BMSCs could survive and migrate. Moreover, BAX, a crucail apopotosis gene, was down-regulated to 0.9 ±0.1 in the BMSC group, compared with 1.1 ±0.2 in the TBI group (P ＜0.05). ConclusionsBMSC transplantation is available to improve the neurological function, as may be associated with the Bax.