Pathogens and prognostic factors of severe pneumonia in AIDS patients
10.3760/cma.j.issn.1674-2397.2011.04.005
- VernacularTitle:AIDS并发重症肺炎病原谱与预后因素分析
- Author:
Xilong DENG
;
Xiaoping TANG
;
Li ZHUO
;
Linghua LI
;
Weiping CAI
;
Xiejie CHEN
- Publication Type:Journal Article
- Keywords:
Acquired immune deficiency syndrome;
Pneumonia;
Pathogen;
Highly active antiretroviral therapy;
Prognosis;
Logistic regression
- From:
Chinese Journal of Clinical Infectious Diseases
2011;04(4):206-209
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the pathogens and prognostic factors of AIDS-associated severe pneumonia. MethodsClinical data were collected from 95 patients with AIDS-associated severe pneumonia admitted to Guangzhou No. 8 People' s Hospital from January 2005 to December 2008. The pathogens of pulmonary infections were investigated. Univariate analysis and multivariate logistic regression analysis were performed to study the relationships between the outcome and influencing factors. Results The most prevalent pathogen was Pneumocystis jirovecii (64/95, 67.4％ ), followed by bacteria (61/95, 64.2％ ),fungi ( 50/95, 52. 6％ ), mycobacterium tuberculosis ( 27/95, 28. 4％ ) and cytomegalovirus ( CMV ) (25/95, 26.3％ ). Among 95 cases, monocontamination was detected in 15 cases ( 15.8％ ), while mixed infection in 80 cases (84. 2％ ). Logistic regression analysis showed that mechanical ventilation, higher serum lactic dehydrogenase (LDH) level and severe underlying diseases were risk factors for the death of AIDS-associated severe pneumonia, and higher serum albumin level was the protective factor. Conclusion Pneumocystis jirovecii, bacteria and fungi are the main pathogens for AIDS-associated severe pneumonia, and mixed infection is popular.
