The prognostic value of HIF-1α and VEGF expression in hypopharyngeal squamous cell carcinoma
10.3760/cma.j.issn.1004-4221.2011.05.007
- VernacularTitle:下咽鳞癌中HIF-1α与VEGF表达的临床治疗意义
- Author:
Ting JIN
;
Fang WANG
;
Weihan HU
;
Nan GE
;
Tao XU
;
Hui LIN
- Publication Type:Journal Article
- Keywords:
Hypoxia-inducible factor lα;
Vascular endothelial growth factor;
Immunohistochemistry;
Hypopharyngeal neoplasms;
Prognosis
- From:
Chinese Journal of Radiation Oncology
2011;20(5):385-389
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo examine the relationship between HIF-1αt and VEGF expression and the clinicopathological characteristics in hypopharyngeal squamous cell carcinoma. Methods The expression status of HIF-1α and VEGF were examined by immunohistochemistric method (IHC) in 62 tumor tissue and 19 paracancerous normal tissue.The relationships between the expression of HIF-1α and VEGF and clinicopathological characteristic were analyzed. Results HIF-1αt and VEGF expression were higher in hypopharyngeal carcinoma tissues than those in paracancerous normal tissues (66. 1％:26. 3％ ;x2 =18. 02,P ＜0. 05 ;67. 7％ : 31.6％ ; x2 =19.22, P ＜ 0. 05 ). The expression intensity of HIF-1 α was related to T stage, N stage and TNM stage ( x2 =4. 23,5.83,9.94,all P ＜0. 05). The expression intensity of VEGF was related to metastasis, T stage, N stage and TNM stage (x2 =5.62,7. 38,15.75,4. 29 ,all P ＜0. 05 ). There was minus relationship between overall survival and expression level of HIF-1 α and/or VEGF (x2 =29. 25, P＜0.01; x2 =24.88, P＜ 0.01 ).On multivariate analysis,HIF-1α expression and T stage were independent prognostic factors for overall survival (x2 =4.80,5.74, all P＜0. 05).ConclusionsHIF-1α and VEGF may be considered as a parameter in evaluation of progression, metastasis and prognosis of hypopharyngeal carcinoma and also may be a direction of molecular target therapy.
