Influence on the prognosis of patients with lymph node micrometastasis of gastric cancer detected by carcinoembryonic antigen detection
10.3760/cma.j.issn.1673-4904.2011.23.002
- VernacularTitle:癌胚抗原检测胃癌淋巴结微转移对患者预后的影响
- Author:
Lianming ZHOU
;
Xueli ZHANG
;
Youhua SHENG
;
Xiaogang LI
;
Ganglong GAO
;
Shiguang WANG
;
Yizhong FENG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Prognosis;
Neoplasm metastasis
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(23):4-7
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of the lymph node micrometastasis and its clinicopathological features on postoperative disease-free survival rate for patients with gastric cancer.Methods The study included 120 patients with pT1-3NoMo gastric cancer. The relationships between clinicopathological features or carcinoembryonic antigen (CEA) positive expression and postoperative disease-free survival rate were analyzed. Results In clinicopathological factors, multivariate analysis identified CEA positive expression was significantly correlated with tumor diameter (P = 0.011 ),depth of tumor invasion (P= 0.027) and lymphatic vessel invasion (P= 0.001 ) in lymph node positively. The average postoperative follow-up was (53.14 ± 16.75) months. There was statistical correlation between the tumor diameter( P = 0.018 ) or depth of tumor invasion ( P = 0.015 ) and postoperative disease-free survival rate. The disease-free survival rate was 90.91% ( 80/88 ), 86.36% ( 19/22 )and 40.00% (4/10) for the lymph node CEA negative,isolated tumor cells (IT Cs) and micrometastasis,respectively. There was significant difference between micrometastasis and the lymph node CEA negative (P= 0.000) or ITCs (P = 0.009), however, the lymph node CEA negative and ITCs was no significant difference (P = 0.438 ). Lymph node micrometastssis of gastric cancer was detected in 10 patients who should belong to stage pN1,the restage rate was 8.33%(10/120). Conclusions If the patients were found micrometastasis in lymph node with high-risk stage pT1-3NoMo gastric cancer for whom chemotherapy may be recommended,because of its high recurrence and poor prognosis.
