Effects of enteral nutrition on intestinal permeability in patients with active ulcerative colitis
10.3760/cma.j.issn.1674-635X.2011.04.004
- VernacularTitle:肠内营养对活动期溃疡性结肠炎患者肠道通透性的影响
- Author:
Youzhe GONG
;
Shutian ZHANG
;
Haifang ZHANG
;
Huibo WU
;
Shujia CHEN
;
Shengtao ZHU
;
Haiying ZHAO
- Publication Type:Journal Article
- Keywords:
Ulcerative colitis;
Enteral nutrition;
Intestinal permeabiliy
- From:
Chinese Journal of Clinical Nutrition
2011;19(4):232-235
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the effects of enteral nutrition (EN) on intestinal permeability in patients with active ulcerative colitis (AUC). MethodsTwenty-four A UC patients were randomly divided into two groups:routine treatment group (n =11 ) and routine treatment plus EN group (n =13). Patients in routine treatment group were treated with mesalazine as well as low-residue diet, while patients in routine treatment plus EN group received mesalazine and short peptide EN for 14 days. The ratio of lactulose to mannitol in urine (L/M) before and after treatment was detected by high-performance liquid chromatography. ResultsThe L/M ratio was 0. 039 ± 0. 025 in routine treatment group and 0.072 ± 0.019 in routine treatment plus EN group (P =0.069). After 2 weeks of treatment, the L/M ratio of routine treatment plus EN group (0.038 ± 0.012 ) was significantly lower than the pretreatment level (P =0.043 ), while the L/M ratio of routine treatment group between before and after treatment had no significant difference (0.039 ± 0.025 vs. 0.032 ± 0.022, P =0.730). ConclusionEN can effectively improve the intestinal permeability in AUC patients.
