Clinical observation of brucea javanica oil emulsion combined with DP chemotherapy in treating advanced non-small-cell lung cancer
10.3760/cma.j.issn.1673-4904.2011.22.005
- VernacularTitle:鸦胆子油乳注射液联合DP方案治疗中晚期非小细胞肺癌的临床观察
- Author:
Haiyu NIU
;
Changping WU
;
Jingting JIANG
;
Bin XU
;
Jiemin ZHAO
;
Wenjie ZHOU
;
Hongbing SHI
;
Qi WANG
;
Wenwei HU
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung;
Brucea javanica;
Antineoplastic combined chemotherapy protocols
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(22):13-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and adverse effects of brucea javanica oil emulsion combined with DP chemotherapy in treating advanced non-small-cell lung cancer.Methods Totally 48 patients with advanced non-small-cell lung cancer were divided into two groups randomly by mechanical sampling method.Twenty-four cases in treatment group were treated by brucea javanica oil emulsion combined with DP chemotherapy, while 24 cases in control group were treated by DP chemotherapy only.The clinical effects were evaluated after treatment of two cycles.Results The short-term effective rate was 54.2% (13/24) in treatment group and 45.8% (11/24) in control group, and there was no significant difference between two groups ( χ2 = 0.333, P = 0.564).The rate of increased and stable life quality was 87.5%(21/24) in treatment group and 58.3%(14/24) in control group,and there was significant difference between two groups (χ2 = 5.169,P = 0.023).The rate of increased and stable weight was 79.2% (19/24) in treatment group and 45.8%( 11/24) in control group, and there was significant difference between two groups (χ2 = 5.689,P = 0.017).The incidence of nausea or vomiting was 45.8% (11/24) in treatment group and 41.7%( 10/24 ) in control group, and there was no significant difference between two groups (χ2 = 0.085, P = 0.771 ).Compared with those in control group, patients in treatment group had less adverse effects in decreasing of peripheral blood leucocytes and showed better immune function.Conclusion Brucea javanica oil emulsion combined with DP chemotherapy in treating advanced non-small-cell lung cancer has good clinical effect, especially enhances the quality of life, improves immune function and decreases the adverse effects of chemotherapy.
