Correlation between carotid atherosclerosis and coronary artery atherosclerosis, and their relationship with peripheral blood macrophage colony stimulatory factor, C-reactive protein and plaque stability
10.3760/cma.j.issn.1673-4904.2011.22.012
- VernacularTitle:冠心病患者颈动脉斑块与冠状动脉斑块的相关性及外周血巨噬细胞集落刺激因子、C反应蛋白与斑块稳定性的关系
- Author:
Wenyuan WANG
;
Sucai AN
- Publication Type:Journal Article
- Keywords:
Macrophage colony-stimulating factor;
C-reactive protein;
Coronary artery plaques;
Carotid plaques
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(22):35-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between carotid atherosclerosis and coronary artery atherosclerosis, and their relationship with macrophage colony stimulatory factor (M-SCF), C-reactive protein(CRP) and plaque stability.Methods A total of 400 patients having underwent a selective coronary angiography were divided into no coronary heart disease (NCHD) group (93 cases), acute coronary artery syndrome(ACS) group (202 cases) and stable angina pectoris(SAP) group ( 105 cases).Based on coronary angiography plaque morphology, the patch was typed as Ⅰ, Ⅱ and Ⅲ and based on ultrasound for the carotid artery, plaque was typed as stable and unstable plaques.The plaque type, the levels of peripheral blood M-SCF, CRP was compared among ACS group,SAP group and NCHD group.Results Coronary artery atherosclerosis was mainly type Ⅱ in ACS group[78.7%(159/202)], and carotid atherosclerosis was mainly unstable[69.3%(140/202)].Coronary artery atherosclerosis of type Ⅰ , Ⅱ , Ⅲ was 40.0%(42/105), 30.5% (32/105) and 29.5%(31/105) in SAP group,and carotid atherosclerosis was mainly stable.The levels of peripheral blood M-SCF, CRP in ACS group were higher than those in SAP group and NCHD group (P＜ 0.05 ) ,and there was no significant difference between SAP group and NCHD group (P＞ 0.05 ).The levels of peripheral blood M-SCF, CRP in coronary artery atherosclerosis with type Ⅱ were higher than those with type Ⅰ , Ⅲ (p＜ 0.05).The levels of peripheral blood M-SCF, CRP in carotid atherosclerosis with unstable plaque were higher than those with stable (P ＜ 0.05 ).Conclusion Coronary arteriosclerosis is closely related with carotid arteriosclerosis.The levels of M-SCF and CRP are related to plaque structural characteristics and plaque stability.
