Relationship between uncoupling protein 2 gene promoter-866 G/A polymorphism and Chinese diabetic nephropathy
10.3760/cma.j.issn.1673-4904.2011.22.001
- VernacularTitle:解耦联蛋白2基因启动子-866G/A多态性与中国人糖尿病肾病的关系
- Author:
Yansun SUN
;
Xia LONG
;
Rong SHI
;
Fan ZHANG
;
Yuanfei DENG
;
Jie YU
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathies;
Genes;
Uncoupling protein 2;
Polymorphism
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(22):1-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between uncoupling protein 2 (UCP-2) gene promoter -866 G/A polymorphism and Chinese diabetic nephropathy (DN). Methods A total of 182 patients with type 2 diabetic mellitus were selected and divided into DN group (90 cases with DN ) and NCD group (92 cases without DN ). Genomic DNA was detected, and UCP-2 genotype and allele gene frequency was confirmed by polymerase chain reaction-restrictive fragment length polymorphism, then compared.Results The genotype frequency of UCP-2 gene promoter-866 G/A polymorphism was distributed in DN group[GG 14.44%( 13/90),GA 31.11%(28/90),AA 54.44%(49/90)],and distributed in NCD group[GG 29.35% ( 27/92 ), GA 32.61% ( 30/92 ), AA 38.04% ( 35/92 )], and there was significant difference between two groups ( χ2 = 7.28 , P ＜ 0.05 ). There was also significant difference in allele gene frequency between DN group and NCD group[G 45.65% (84/184) vs. 30.00% (54/180),A 54.35% (100/184) vs. 70.00% (126/180)]( χ2 = 9.47, P ＜ 0.05 ). Conclusion There is correlation between the UCP-2 gene promoter-866 G/A polymorphism and Chinese DN, and the incidence of DN with A/A genotype is increased.
