Nutritional therapy on the prognosis of severe acute pancreatitis

VernacularTitle:营养治疗对重症急性胰腺炎预后的影响
Author: Renbao YANG ; Jiong CHEN
Publication Type:Journal Article
Keywords: Severe acute pancreatitis; Enteral nutrition; Parenteral nutrition; Meta-analysis
From: International Journal of Surgery 2011;38(8):522-528
CountryChina
Language:Chinese
Abstract: Objective To study the effect of enteral nutrition(EN) and total parenteral nutrition(TPN)on patients with severe acute pancreatitis by a Meta analysis.Method s Randomized controlled trials of EN in patients with severe acute pancreatitis were searched in Cochrane library,Pubmed database,CNKI database,CBM database.Data were searched by two statisticians.RevMan 5.0 was applied for statistical analysis.Results Nine randomized controlled trials were enrolled into this analysis.Meta-analysis indicated that the use of enteral nutrition decreased the incidence of infectious complications(RR was 0.37,95% CI[0.18,0.77]),pancreas infectious complications (RR was 0.44,95% CI [0.24,0.81],P ＜ 0.01),MODS (RR was 0.33,95% CI[0.19,0.56]),mortaily (RR was 0.45,95% CI [0.26,0.80]),surgical interventions (RR was 0.51,95% CI [0.36,0.71]).When starting within 48 h of admission,EN,in comparison with TPN,resulted in a statistically significant reduction in the risk of MODS,mortaily and infectious complications.Conclusion For patients with severe acute pancreatitis,early EN therapy is better than TPN.