Ki-67 expression in T1 primary breast cancer tissue and its relationship with Her-2 and ER
10.3760/cma.j.issn.1673-4203.2011.08.007
- VernacularTitle:Ki-67在T1期乳腺癌中的表达及其与Her-2和ER的关系
- Author:
Yu WEI
- Publication Type:Journal Article
- Keywords:
Ki-67;
T1 primary breast cancer;
Her-2;
ER
- From:
International Journal of Surgery
2011;38(8):529-531
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of Ki-67 in T1 primary breast cancer tissue and its relationship with Her-2 and ER,evaluate the prognosis of early breast cancer.Method s Sixty cases of women T1 primary breast cancer tissues of 60 female cases from January 2008 to June 2011 were selected.The expressions of Ki-67 were detected by immunohistochemieal method and the relationships between Ki-67 and clinical-pathological fcatures,Her-2 and ER were analysed.Results The expression of Ki-67 in T1 primary breast cancer was 55% among the 60 patients.The expression of Ki-67 was not related with the clinical-pathological type of breast cancer and menopause (P＞0.05).The expression of Ki-67 in group with lymph node metastasis was higer than in group without lymph node metastasis(P =0.047 ,P ＜0.05).The expression of Ki-67 in Her-2positive group was higher than Her-2 negative group (P= 0.021,P＜0.05),and the expression of Ki-67 in ER positive group was lower than that of ER negative group (P = 0.037,P ＜ 0.05).Conclusions The expression of Ki-67 in T1 primary breast cancer indicates the possibility of lymph node metastasis,and its positive correlation with Her-2 positive expression,ER negative expression indicates poor prognosis.
