A study of relationship between obstructive sleep apnea-hypopnea syndrome in hypertension and insulin
10.3760/cma.j.issn.0578-1426.2011.09.015
- VernacularTitle:高血压合并阻塞性睡眠呼吸暂停低通气综合征与胰岛素相关性研究
- Author:
Yunwei BI
;
Zhitao YAN
;
Nanfang LI
;
Weiping CHENG
;
Ruimei HAN
;
Lili ZHANG
;
Yingchun WANG
;
Xinling WANG
;
Feiya ZU
- Publication Type:Journal Article
- Keywords:
Hypertension;
Sleep apnea,obstructive;
Insulin resistance;
Blood glucose
- From:
Chinese Journal of Internal Medicine
2011;50(9):734-737
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the obstructive sleep apnea-hypopnea syndrome(OSAHS) in hypertension and insulin.Methods A total of 521 patients were divided into 4 groups according to apnea-hypopnea index and OSAHS degrees.The control group ( group Ⅰ ),mild OSAHS group ( group Ⅱ ),moderate OSAHS group ( group Ⅲ ) and severe OSAHS group ( group Ⅳ ) had 89 patients,194 patients,118 patients and 120 patients respectively.Results The BMI[( 30.4 ± 3.8 )kg/m2],apnea-hypopnea index ( AHI,3.8 ± 0.1 ),Fasting insulin (FIns)[(3.08 ± 0.26 ) mU/L]and insulin resistance ( 2.43 ± 0.27 ) of patients in severe OSAHS group were significantly higher than that of in the control,mild OSAHS group and moderate OSAHS group ( P ＜ 0.01 ).The levels of saturation of minimum oxygen from skin of patients in severe OSAHS group was significantly lower ( MSpO2 ) than in that of the control,mild OSAHS group and moderate OSAHS group.Multiple linear regression analysis showed that fasting plasma insulin and insulin resistance was positive correlation with apnea-hypopnea index,while they also negatively associated with saturation of minimum oxygen.Conclusions FIns and insulin resistance strongly associate with AHI and levels of saturation of minimum oxygen from skin.Hypertensive patients with OSAHS have more chances to suffer with insulin resistance.
