Association study of 5-HTR2A promoter region gene polymorphisms with unipolar depression and paroxetine treatment response in northwest Chinese Han population
10.3760/cma.j.issn.1674-6554.2011.08.011
- VernacularTitle:中国西北地区汉族人群5-羟色胺2A启动区基因多态性与单项抑郁症及抗抑郁药物疗效的关联性研究
- Author:
Wenhua LIU
;
Lan ZHANG
;
Hong YIN
;
Jianxun LUO
- Publication Type:Journal Article
- Keywords:
Uuipolar depression;
5-HT2A receptor promoter region;
Gene polymorphism
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2011;20(8):704-706
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between the 5-HTR2A (-1438A/G)promoter region gene polymorphisms and unipolar depression and effcacy of antidepressant drugs in northwest Chinese Han population.Methods Polymerase chain reaction (PCR) was used to detect the distributive frequency of serotonin 2A receptor promoter region polymorphisms of 136 unipolar depression patients( patient group) and 160 normal people tween the patient group and the control group.The frequency of AG,GG genotypes; and G allele in patients was phisms of 5-HT2AR promoter region were correlated with SSRIs treatment response(F= 6.317, P= 0.013 ).There was significant difference of the effective power at the end of week 2 ( x2 = 5.878, P= 0.015 ).The effective power of AA, AG genotype was much higher than that of GG genotype and the effective power in the group with AA genotype was higher than that with AG genotype( each 87.8% ,57.6% ,53.7% ).Conclusion The frequency of GG genotype of 5-HTR2A( 1348A/G)may be associated with episode of unipolar depression in northwest Chinese Han population and A allele may be correlated with well response to paroxetine.
