Alanine aminotransferase and aspartate aminotransferase levels are sensitive indicators for liver inflammation grading in HBeAg-negative chronic hepatitis B patients
10.3760/cma.j.issn.1000-6680.2011.08.005
- VernacularTitle:丙氨酸转氨酶和天冬氨酸转氨酶是反映HBeAg阴性慢性乙型肝炎肝组织炎性分级的敏感指标
- Author:
Shaoquan ZHANG
;
Jing LAI
;
Shibin XIE
;
Xiaohong ZHANG
;
Ying ZHANG
;
Zhixin ZHAO
;
Weimin KE
;
Zhiliang GAO
- Publication Type:Journal Article
- Keywords:
Inflammation;
Alanine aminotransferase;
Aspartate aminotransferases;
Hepatitis B,chronic;
Hepatitis B e antigens
- From:
Chinese Journal of Infectious Diseases
2011;29(8):463-467
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum levels of alanine aminotransferase (ALT)or aspartate aminotransferase (AST)apportioned by the same hepatic parenchyma cell volume and liver histological necroinflammation grades in HBeAg-negative chronic hepatitis B (CHB)patients.Methods A total of 145 CHB patients were divided into four groups:Gl,G2,G3 and G4 based on the liver histological necroinflammation grade.The serum ALT and AST levels were determined by automatic biochemical instrument in these four groups.Furthermore,serum ALT and AST levels were then apportioned by the same hepatic parenchyma cell volume.The data were analyzed by ANOVA.Results Mean serum ALT levels in G1,G2,G3 and G4 groups were (35.3±29.1),(91.6±120.4),(111.6± 116.1)and (118.0±122.1)U/L,respectively,and the serum ALT levels apportioned by same hepatic parenchyma cell volume were ( 54.0 ± 45.1 ),( 144.2 ± 184.9 ),(191.3± 204.8)and (215.1 ± 226.5)U/L,respectively.The pairwise comparison between G1 and other three groups all showed statistically significant difference (P＜0.05).Meanwhile,AST levels in G1 to G4 groups were (35.5± 29.0),(64.9±71.7),(96.0±81.9)and (102.8±77.0)U/L,respectively and the serum AST levels apportioned by the same hepatic parenchyma cell volume were (54.3±44.6),(102.3± 107.9),(165.2±148.7)and (189.4±145.4)U/L,respectively.The pairwise comparison between G1 and G3,G1 and G4,G2 and G3,G2 and G4 all showed statistically significant difference (P＜0.05).Conclusion Both AST and ALT levels are sensitive indicators for liver inflammation grading in HBeAg-negative CHB patients during the natural history of the disease.
