Prediction of lymph node metastasis of gastric cancer patients
10.3760/cma.j.issn.1673-4203.2011.08.011
- VernacularTitle:胃癌患者淋巴转移的预测分析
- Author:
Renxiong CHEN
;
Jun ZHANG
;
Zhongtao ZHANG
;
Kangli WANG
;
Jianshe LI
;
Lan JIN
;
Yu WANG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Lymph node metastasis;
Logistic regression analysis
- From:
International Journal of Surgery
2011;38(8):540-542
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study aimed to establish a prediction system of lymph node metastasis of gastric cancer patients,to facilitate guiding the treatment of patients with gastric cancer.Method s We analyzed 255 cases of gastric cancer from January 2005 to December 2009 in Beijing Friendship Hospital.They all had surgery or palliative gastrectomy and then examined pathological lymph node metastasis.Their gender,age,preoperative weight loss,anemia,pyloric obstruction,chronic disease history,family history,tumor location,tumor size,higher preoperative CEA,preoperative tumor markers (CEA,AFP,CA199,CA125)elevationed (one or more),preoperative choline esterase,preoperative albumin,preoperative hemoglobin,preoperative platelet and preoperative urinary protein were made Logistic regression analysis.Results The combination of preoperative tumor size,higher tumor markers (CEA,AFP,CA199,CA125) in one or more was possible for lymph node metastasis prediction.The area under ROC curve was about 100%,Showing high discriminant ability.Conclusions The tumor size and preoperative tumor markers (CEA,AFP,CA199,CA125) are important predictive parameters for lymph node metastasis of gastric cancer.Tumor size combined with the preoperative tumor markers (CEA,AFP,CA199,CA125) predicting lymph node metastasis can help us to carry out other work,such as neoadjuvant therapy,etc.
