Comparison of the pharmacokinetics differences between the combination of cyclophosphamide and cisplatin and single medication
10.3760/cma.j.issn.1006-9801.2012.10.012
- VernacularTitle:环磷酰胺、顺铂联合用药与单一用药的药代动力学比较
- Author:
Zhiying HAO
;
Yadong LI
;
Qingshan LI
;
Zhiqin LIU
- Publication Type:Journal Article
- Keywords:
Cyclophosphamide;
Cisplatin;
Pharmacokinetics;
Comparative effectiveness research
- From:
Cancer Research and Clinic
2012;24(10):688-691
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pharmacokinetic difference between the combination of cyclophosphamide and cisplatin and single medication.Methods High performance liquid chromatography (HPLC) was used to detect the pharmacokinetic parameters and distribution parameters in tissue of cisplatin and cyclophosphamide.Results The pharmacokinetic curve of the CP regimen showed two-compartment model,and there was no significant difference between the absorption half life of the combination of the two drugs (0.56±0.02,0.72±0.02) and that of single medication (0.92±0.02,1.16±0.12) (t =2.091,t =2.379,both P ＞ 0.05).While the elimination half life of the combination (0.56±0.02,0.72±0.02) was significantly longer compared with that of single medication (0.92±0.02,1.16±0.12) and there were significant differences (t =5.796,t =6.213,both P ＜ 0.05).There was no significant difference of MRT in heart between the disturbution of the combination of the two drugs and that of single medication (t =2.231,t =2.096,both P ＞ 0.05).While there was significantly longer compared with that of single medication and there were significant differences in lung and liver (t =5.976,t =6.270,both P ＜ 0.05).Conclusion When used in combination,the elimination of the drugs is slower,which suggests that the interval and dosage of the drugs should be adjusted to their pharmacokinetic parameters in clinical use to improve effects and lower side effects.
