Correlation analysis between K-ras gene mutation and clinicopathological characteristics in colorectal cancer
10.3760/cma.j.issn.1006-9801.2012.10.004
- VernacularTitle:结直肠癌K-ras基因突变与临床病理特征的相关性分析
- Author:
Fangfang ZHANG
;
Jianmin LI
;
Yuehua WANG
;
Ning GAO
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
K-ras;
Genes mutation
- From:
Cancer Research and Clinic
2012;24(10):659-662
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate mutations of oncogene K-ras in colorectal cancer tissues and the relationship between mutations of K-ras and clinicopathological characteristics in colorectal cancer.Methods Specimens of 90 patients with colorectal cancer were detected K-ras gene by direct sequencing.Then satistical analysis were used to analyzed the associations between K-ras mutation status and clinicopathological characteristics in colorectal cancer.Results 31 cases were detected mutation in 90 cases of colorectal cancer specimens.The total mutation rate of K-ras was 34.4 ％.There were 21 eases of single mutation occurred in codon 12.One case had double mutation in codon 12.9 cases mutation were occurred in codon 13.There were significant difference between K-ras mutation rate and the location of tumor (P =0.042).The frequency of 12/13 codon mutation was no correlated with age,gender,tumor size,dukes stage,hepatic metastases,location of tumor.Conclusion The rate of K-ras mutation is correlated with the location of tumor.
