Investigation of lung cancer susceptibility correlated with polymorphism of DNA repair gene XRCC and hOGG1
10.3760/cma.j.issn.1006-9801.2012.09.023
- VernacularTitle:DNA损伤修复基因XRCC和hOGG1多态性与肺癌易感性的关系
- Author:
Yun LIU
;
Daokui XIA
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
DNA repair gene;
XRCC;
hOGG1;
Genetic polymorphism
- From:
Cancer Research and Clinic
2012;24(9):642-644
- CountryChina
- Language:Chinese
-
Abstract:
DNA repair gene polymorphism can change the functions and efficiency of DNA repair,influence cancer susceptibility.Many studies have been reported that DNA damage repair gene polymorphisms may be related to cancer susceptibility mutation in a variety of tumors and plays an important role in the pathological process.In addition,DNA damage repair genes may interact with other genes,the combined effect of tumor occurrence,development.Lung cancer is the well-studied tumor in this respect.In this paper,DNA damage repair gene XRCC and hOGG1 polymorphisms biological characteristics,these gene single nucleotide polymorphisms as well as cancer susceptibility were reviewed to provide a theoretical basis for the tumor prevention,diagnosis and treatment.
