Correlation and its clinical significance of regulatory T cells and NKG2D-expressing NK cells in lung cancer patients
10.3760/cma.j.issn.1006-9801.2012.09.006
- VernacularTitle:肺癌患者调节性T细胞与NK细胞活化受体NKG2D的相关性及其临床意义
- Author:
Yusen HOU
;
Wen SU
;
Yanfeng WANG
;
Zhihua TIAN
;
Fucai LIU
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Treg;
NK;
NKG2D;
Immune escape
- From:
Cancer Research and Clinic
2012;24(9):597-599
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the levels of CD+4 CDHi25 CDLo127 regulatory T (Treg) cells and NKG2D-expressing NK cells in peripheral blood of lung cancer patients and investigate their relationship,and explore their roles in the immune escape of lung cancer and clinical significance.Methods The levels of CD+4 CDHi25 CDLo127 Treg cells,NK cells and NKG2D-expressing NK cells were measured in peripheral blood of 70 lung cancer patients and 50 healthy controls.Results Compared with control group,the levels of CD+4 CDHi25 CDLo127 Treg cells enormously increased [(8.4±4.1) ％,(6.7±1.7) ％] (t =3.09,P ＜ 0.05),while the value of NKG2D obviously decreased [(83.3±4.9) ％,(87.4±2.9) ％] (t =3.16,P ＜ 0.05); And the group of NK cells is not different [(15.6±8.3) ％,(17.2±4.2) ％] (t =-1.33,P ＞ 0.05); NKG2D-expressing NK cells had a perfect negative correlation with CD+4 CDLo25 CDLo127 Treg cells (r =-0.302,P ＜ 0.05).Conclusion Accumulation of Treg cells in serum may lead to the down-modulation of NKG2D-expressing NK which participates the tumor immune escape.They may be potential indicators evaluating immune functions and prognosis of lung cancers.
