Expression patterns of interleukin-17 and matrix metalloproteinase-9 in non-small cell lung cancer and their relationship with pTNM stage

VernacularTitle:非小细胞肺癌组织中白细胞介素17、基质金属蛋白酶9表达与pTNM分期的关系
Author: Feng HAN ; Xiaomei MA ; Guoqing ZHANG ; Xinzhi FANG
Publication Type:Journal Article
Keywords: Interleukin-17; Matrix metalloproteinase 9; Carcinoma,non-small-cell lung; pTNM stage
From: Cancer Research and Clinic 2012;24(9):580-583
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of interleukin-17 (IL-17) and matrix metalloproteinase-9 (MMP-9) in non-small cell lung cancer (NSCLC) and their relationship with pTNM staging.Methods IL-17 and MMP-9 expressions in cancer and adjacent tissues were detected from 102 cases of NSCLC by immunohistochemistry.x2 test was used to compare the ratio of their relationship with the pTNM stage.Results IL-17,MMP-9 expression rates in NSCLC cancer were 73.53 ％ (75/102),60.78 ％ (62/102)respectively,IL-17,MMP-9 expressions in different TNM stages were statistically significant correlated (P ＜ 0.05) respectively.The expression of IL-17 and MMP-9 in NSCLC tumor tissue were related statistically (P ＜ 0.05),and adjacent tissues were not related (P ＞ 0.05).Conclusion IL-17,MMP-9 in NSCLC tissues were significant increased,both may be involved in invasion and metastasis of NSCLC,IL-17 and MMP-9 were correlated in NSCLC tumor tissue but not in adjacent tissues.