Clinical analysis of thirty-four blue rubber bleb nevus syndrome cases

Yanzhi Wang; Yunsheng Yang; Fengchun Cai; Wen LI; Yan Dou; Zhen LI; Mingzhou Guo

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Clinical analysis of thirty-four blue rubber bleb nevus syndrome cases

VernacularTitle:蓝色橡皮大疱痣综合征34例临床分析
Author: Yanzhi WANG ; Yunsheng YANG ; Fengchun CAI ; Wen LI ; Yan DOU ; Zhen LI ; Mingzhou GUO
Publication Type:Journal Article
Keywords: Nevus,blue; Gastrointestinal neoplasms; Blister; Skin neoplasms; Hemorrhage,gastrointestinal; Endoscopy
From: Chinese Journal of Digestion 2012;32(11):723-726
CountryChina
Language:Chinese
Abstract: Objective To summarize and analyze the clinical characteristic of blue rubber bleb nevus syndrome (BRBNS).Methods The clinical data of four cases treated since 2001 and 30 BRBNS cases reported by domestic literature were retrospectively analyzed.The clinical manifestation,family history,endoscopy and imageology examination,site of lesions,treatment and follow up were analyzed.Results The male to female ratio was 1.8∶1 and median age was 19.5 years.A total of 33 cases (97.1％) presented with gastrointestinal bleeding,median age of gastrointestinal bleeding detected was 9.0 years.Among the 33 cases,anemiawas found as the primary symptom in nine cases (27.3％),and one case complicated with intussusception and intestinal necrosis accompanied with abdominal pain.Two cases have family history.Gastroscopy (85.3 ％) and colonoscopy(73.5 ％) were mainly examinations for detection.Lesions mainly involved skin (100.0％) and digestive tract (97.1％),and the locations of the lesion in digestive tract was stomach (64.7％),small intestine (64.7％),colon (58.8％),esophagus (29.4％).Treatment methods included symptomatic treatment,endoscopic therapy and surgery.Banding ligation and polypectomy resection were common endoscopic therapies.Gastrointestinal bleeding did not recur in six cases with endoscopic therapy and four cases receiving surgery during short-term follow up.Conclusions BRBNS lesions mainly involve skin and digestive tract,mostly complicated with gastrointestinal bleeding.For gastrointestinal bleeding,so far endoscopic therapy and surgery are the effective therapies.