The changes of Th17 and regulatory T cells in the process of anti-tuberculosis treatment of tuberculosis patients
10.3760/cma.j.issn.0254-5101.2012.09.013
- VernacularTitle:肺结核患者Th17和调节性T细胞在抗结核治疗过程中的变化
- Author:
Jing LI
;
Yan HE
;
Yuhuang ZHENG
;
Yanke LIU
;
Ke YIN
;
Wenjun FENG
;
Xiaoyun YANG
;
Chaoqun LIU
;
Fang HE
;
Manying QU
;
Chenglin OUYANG
- Publication Type:Journal Article
- Keywords:
Tuberculosis;
Th17 cell;
Regulatory T cell (Tr);
Anti-tuberculosis
- From:
Chinese Journal of Microbiology and Immunology
2012;32(9):813-815
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the Th17 and regulatory T cells(Tr) equilibrium state as well as their changes of tuberculosis patients in six-month's anti-Tuberculosis treatment.Methods Select thirty-two tuberculosis patients received anti-Tuberculosis treatment while thirty-two healthy volunteers as controls.Flow cytometry was used to analyze Th17 and Tr cells in venous blood at the time of pre-therapy,3th,6th month.Results The ratio of Th17 cells in CD4 cells in tuberculosis patients and volunteers were (1.10±0.39)％,(2.50±1.03) ％,(3.90±1.34) ％,(4.50±1.52)％,respectively; the ratio of Tr cells were (9.17±3.26)％,(6.85±2.73)％,(5.46±1.69)％,(4.35±0.86)％,respectively.Conclusion Tuberculosis could make Th17 cells and Tr cells lost their balance,but the immune equilibrium state may gradually recover after anti-tuberculosis.The change of the amount of immune cells was likely to be the reference indexes to observe the progress of tuberculosis and the treatment effect of anti-tuberculosis.
