Identification of a novel allele, HLA-B * 54∶26

VernacularTitle:新等位基因HLA-B*54∶26的序列鉴定
Author: Yongbao ZHU ; Chuanfu ZHU ; Wenben QIAO ; Yi ZHANG
Publication Type:Journal Article
Keywords: HLA; Novel allele; B*54∶26; Sequenced based typing(SBT)
From: Chinese Journal of Microbiology and Immunology 2012;32(7):652-654
CountryChina
Language:Chinese
Abstract: Objective To identify a novel HLA-B allele in Chinese Han population.Methods No full matched result was obtained in HLA-B locus in HLA typing for China marrow donor program(CMDP) using bi-allelic sequence-based typing(SBT).A confirmatory test for novel HLA allele was performed with mono-allelic SBT.Results B * 15∶05∶01 was confirmed and another allele should be a B * 54new.The B * 54new has 2 nt changes from the closest matching HLA-B * 54∶01∶01 at nt 559,560 where AC→GA(codon163ACG→GAG),led to a coding change,163T→E.Conclusion A novel HLA-B allele was confirmed and officially named HLA-B * 54∶26 under the Genbank Accession number JN209963 by the WHO Nomenclature Committee for Factors of the HLA System in February 2012.